Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma
نویسندگان
چکیده
In this work, we used a preparation of diminazene, which belongs to the group of aromatic diamidines. This compound acts on the causative agents of blood protozoan diseases produced by both flagellated protozoa (Trypanosoma) and members of the class Piroplasmida (Babesia, Theileria, and Cytauxzoon) in various domestic and wild animals, and it is widely used in veterinary medicine. We examined the behavior of water-disperse diminazene (immobilized in Tween 80 micelles) at the cellular and organismal levels. We assessed the interaction of an aqueous and a water-disperse preparation with cells of the reticuloendothelial system. We compared the kinetic parameters of aqueous and water-disperse diminazene in sheep erythrocytes and plasma. The therapeutic properties of these two preparations were also compared. We found that the surface-active substances improved intracellular penetration of the active substance through interaction with the cell membrane. In sheep blood erythrocytes, micellar diminazene accumulated more than its aqueous analog. This form was also more effective therapeutically than the aqueous analog. Our findings demonstrate that use of micellar diminazene allows the injection dose to be reduced by 30%.
منابع مشابه
PERFORMANCE MODEL AND ANALYSIS OF BLOOD FLOW IN SMALL VESSELS WITH MAGNETIC EFFECTS
In this paper consider a two-fluid model consisting of a core region of suspension of all the erythrocytes (particles) in plasma (fluid) assumed to be a particle-fluid mixture and a peripheral layer of cell-free plasma (Newtonian fluid), has been proposed to represent blood flow in small diameter tubes with effects of magnetic. The analytical results obtained in the proposed model for effective...
متن کاملPrevalence and chemotherapy of babesiosis among Lohi sheep in the Livestock Experiment Station, Qadirabad, Pakistan, and environs
A total of 310 blood smears were collected from sheep of the Livestock Experiment Station, Qadirabad, Sahiwal district, Pakistan, and surrounding areas. The samples were examined microscopically and 30 (9.67%) were positive for babesiosis. The animals were divided into two groups (A and B) for chemotherapy. Group A sheep were treated with diminazene diaceturate while group B animals received im...
متن کاملEffects of Matricaria chamomille and Cichorium intybus powder on Performance, Rumen Microbial Population and Some Blood Parameters of Dallagh Sheep
BACKGROUND: Manipulation of rumen microbial population for improving animal performance is done by several methods including medicinal plants. Matricaria chamomille (chamomile) and Cichorium intybus (chicory) are two medicinal plant with antibacterial effect that there is little information about the effects of them on rumen microflora. OBJECTIVE: The present study was carried out to evaluate t...
متن کاملSelenium and iodine status of sheep in the Markazi province, Iran
The aim of this study was to provide preliminary quantitative information on selenium and iodine statusof sheep in Markazi province, Iran. Selenium and iodine status of grazing sheep were measured for 57different flocks in 14 regions over one year. The districts were selected to represent major sheep growingareas in the province. Blood samples were collected from 2 to 3-year-old ewes during sum...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2011